Correlation among blood lipids and main inflammatory factors levels in patients with coronary heart disease complicated hyperlipidemia
10.3969/j.issn.1008-0074.2017.04.10
- VernacularTitle:冠心病合并高脂血症患者血脂水平与主要炎症因子的相关性
- Author:
Zhengjun SHEN
- Keywords:
Coronary disease;
Hyperlipidemia;
Inflammation
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2017;26(4):388-390
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study correlation among blood lipids and main inflammatory factors levels in patients with coronary heart disease (CHD) complicated hyperlipidemia.Methods: A total of 130 CHD patients treated in our hospital were selected.According to blood lipid level, they were divided into hyperlipidemia group (n=90) and non-hyperlipidemia group (n=40).Levels of total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), high sensitive C reactive protein (hsCRP), interleukin (IL)-6 and tumor necrosis factor (TNF)-α were measured and compared between two groups.Results: Compared with non-hyperlipidemia group, there were significant rise in levels of hsCRP [(1.52±0.89) mg/L vs.(9.03±1.04) mg/L], IL-6 [(10.52±2.41) mg/L vs.(35.63±3.08) mg/L] and TNF-α [(1.04±0.04) μg/L vs.(10.08±0.25) μg/L] in hyperlipidemia group, P=0.001 all.Pearson correlation analysis indicated that levels of TC, TG and LDL-C were significant positively correlated with levels of hsCRP, IL-6 and TNF-α (r=0.603~0.843, P<0.05 or <0.01), and HDL-C level was significant inversely correlated with levels of hsCRP, IL-6 and TNF-α (r=-0.853~-0.742, P<0.01 all) in hyperlipidemia group.Conclusion: Blood lipid levels are significantly correlated with inflammatory factors levels in patients with coronary heart disease complicated hyperlipidemia.Regulation of blood lipid levels can control inflammatory factors levels, which may have an active effect on prognosis.
