Therapeutic effect of recombinant human brain natriuretic peptide on aged patients with acute decompensated heart failure
10.3969/j.issn.1008-0074.2017.04.12
- VernacularTitle:重组人脑钠肽治疗老年急性失代偿期心力衰竭患者的疗效
- Author:
Daobing JI
;
Xintao ZHOU
;
Hao XU
;
Libing ZHAO
;
Xiaofang HU
;
Qiufang ZHANG
- Keywords:
Heart failure;
Natriuretic peptide,brain;
Ventricular function
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2017;26(4):395-398
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore therapeutic effect of recombinant human brain natriuretic peptide (rhBNP) in aged patients with acute decompensated heart failure (ADHF).Methods: A total of 98 aged ADHF patients treated in our hospital were selected and randomly divided into routine treatment group (n=50) and rhBNP group (n=48, received intravenous injection of rhBNP based on routine treatment group).After 72h treatment, cardiac function indexes, total effective rate and incidence of adverse drug reactions (ADR) were measured and compared between two groups.Results: Compared with before treatment, after 72h treatment, there were significant rise in left ventricular ejection fraction (LVEF) and 24h urine volume in both groups(P=0.001 all);compared with routine treatment group after treatment, there were significant rise in LVEF [(45.9±7.8)% vs.(57.4±7.9)%] and 24h urine volume [(1637.5±103.2)ml vs.(1836.4±118.4)ml], P=0.001 all.On 7d after treatment, total effective rate of rhBNP group was significantly higher than that of routine treatment group (93.75% vs.82.00%, P=0.033).There was no significant difference in incidence rate of ADR between two groups, P=0.898.Conclusion: Recombinant human brain natriuretic peptide can significantly improve heart function, and the therapeutic effect is significant in aged patients with acute decompensated heart failure.
