Optimal scan time of MRI with alpha-methyl-L-tryptophan superparamagnetic iron oxide nanoparticles for temporal lobe epilepsy
10.3760/cma.j.issn.2095-2848.2017.04.007
- VernacularTitle:螯合α-甲基色氨酸的超顺磁性氧化铁纳米粒子用于颞叶癫(癎)MRI的最佳扫描时间探讨
- Author:
Tingting FU
;
Qingxia KONG
;
Huaqiang SHENG
;
Lingyun GAO
- Keywords:
Magnetite nanoparticles;
Tryptophan;
Epilepsy,temporal lobe;
Magnetic resonance imaging;
Rats
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2017;37(4):220-224
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the optimal scan time of MRI using the imaging probe alphamethyl-L-tryptophan(α-MTrp)-superparamagnetic iron oxide nanoparticles (SPIONs) for localizing temporal lobe epilepsy (TLE) foci.Methods α-MTrp-SPIONs were injected into rat models of TLE through the tail vein during the acute and chronic stages (72 h and 8 weeks after status epilepticus,respectively).MRI was performed before and 1,2,4,8,24 h after the injection in all animals,and the T2 values of the epileptogenic regions were measured.One-way repeated measures analysis of variance was used for data analysis.Results Compared with the T2 values before the injection of α-MTrp-SPIONs,the T2 signal of epileptogenic regions after the injection had a negative increased change.The T2 values before and 1,2,4,8,24 h after the injection in acute stage were 112.08±5.85,107.83±6.59,105.08±6.79,95.58±5.14,100.92± 5.81,105.17±6.31 respectively,and those in chronic stage were 112.08±7.53,107.75±7.10,102.75± 5.50,96.17±5.01,97.75±4.37,102.92±4.74.The T2 values after the injection were significantly different from those before the injection (both P＜0.01).The T2 value at 4 h after the injection decreased mostly.Conclusions α-MTrp-SPIONs can precisely localize epileptogenic regions of TLE on MRI.The optimal scan time is 4 h after the injection.
