Development of PET agent for cardiac sympathetic nervous system
10.3760/cma.j.issn.2095-2848.2017.04.012
- VernacularTitle:心脏交感神经正电子显像剂的研究进展
- Author:
Yulin HE
;
Jinming ZHANG
- Keywords:
Radioactive tracers;
Positron-emission tomography;
Sympathetic nervous system;
Heart;
Trends
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2017;37(4):237-239
- CountryChina
- Language:Chinese
-
Abstract:
Many cardiac sympathetic changes occur before clinical symptoms being found in heart disease.PET/CT imaging can sensitively detect abnormal cardiac sympathetic nerve function.The recent development of several 11 C and 18F labeled cardiac sympathetic imaging agents is reviewed in this paper.11C-meta-hydroxyephedrine (11 C-HED) and 6-18F-fluorodopamine (18F-FDA) have been comprehensively studied already.N-11C-CH3-dopamine (11C-MDA) and N-(3-bromo-4-(3-18F-fluoropropoxy)-benzyl)-guanidine (18F-LMI1195) are novel imaging agents with potential for clinical application.
