Adverse Reaction to Methotrexate and Etretinate in a Patient with Psoriasis.
10.5021/ad.1989.1.1.59
- Author:
Ee Seok LIM
;
Myeung Nam KIM
;
Byung In RO
;
Chin Yo CHANG
- Publication Type:Case Report
- Keywords:
Adverse reaction;
Etretinate;
Methotrexate;
Psoriasis
- MeSH:
Acitretin*;
Blood Cell Count;
Candida albicans;
Etretinate*;
Fever;
Hair;
Humans;
Leukopenia;
Lower Extremity;
Male;
Methotrexate*;
Middle Aged;
Mouth;
Prednisolone;
Psoriasis*;
Scalp;
Skin;
Thrombocytopenia;
Ulcer
- From:Annals of Dermatology
1989;1(1):59-63
- CountryRepublic of Korea
- Language:English
-
Abstract:
A 49-year-old Caucasian male patient suffered from fever general weakness and diffuse hair loss on the scalp for 3 days. Skin lesions showed erythematous scaly patches with pustules and erosions on the lower extremities and perianal region, and multiple ulcerations on the labial mucoas. A complete blood cell count revealed thrombocytopenia and leukopenia, which gradually worsened day after day (platelet: 29, 000/mm², WBC: 1,000/mm³). Candida albicans was isolated from the lesions of the oral cavity and lower extremities. Twelve days prior to the visit, he had taken etretinate Tegison®) P.O.25mg/day, prednisolone P.O. 50mg1dy and methotrexate P.O. 15mg/day for 5 days for the treatment of psoriasis. We presume that these adverse reactions may be synergistic adverse reactions, probably due to methotrexate and etretinate in consideration of the patient's history.
