Progress in pharmacological effects and clinical applications of berberine
10.3867/j.issn.1000-3002.2017.06.001
- VernacularTitle:小檗碱药理作用及其临床应用研究进展
- Author:
Yu XING
;
Xin LIU
;
Yuan LIN
;
Yong ZHANG
- Keywords:
berberine;
anti-microorganisms;
anti-inflammatory;
anti-cancer;
cardiac protection;
regulate lipid metabolism;
glucose lowering;
immune suppression
- From:
Chinese Journal of Pharmacology and Toxicology
2017;31(6):491-502
- CountryChina
- Language:Chinese
-
Abstract:
Berberine is an isoquinoline alkaloid isolated from Rhizoma Coptidis and Cortex Phellodendri,which has a long medical history in China.Recent studies have indicated that berberine has multiple pharmacological activities including anti-inflammatory,anti-microorganisms,anti-cancer,cardiac protection,glucose lowering,regulating lipid metabolism and immune suppression.Berberine has been used for the treatment of intestinal infectious diseases for many years.With the continuous progress of the research,it is reported that berberine has many new clinical applications,including treatment of the cardiovascular disease,metabolic syndrome and its complications,cancers,abdominal adhesions and chlamydia trachomatis infection.This review is intended to introduce the role of berberine in various aspects of pharmacological effects,molecular mechanisms and clinical applications.
