Expression pattern of FoxN1 gene and response to low temperature in Min pig
10.16303/j.cnki.1005-4545.2017.08.29
- VernacularTitle:民猪FoxN1基因的表达规律及对低温应答反应
- Author:
Dongjie ZHANG
;
Ling LI
;
Xinxin WANG
;
Liang WANG
;
Guowei YANG
;
Di LIU
- Keywords:
Minzhu;
large white pig;
thymus;
FoxN1 gene
- From:
Chinese Journal of Veterinary Science
2017;37(8):1589-1593,1604
- CountryChina
- Language:Chinese
-
Abstract:
Thymus is an important immune organ in mammals.FoxN1 plays an important role in regulating the development of thymic epithelial cells.Pig is a domestic animal of meat type,and is also a new kind of experimental animal model.In order to better understand the development characteristics of pig own immunity,the expression pattern of Minzhu FoxN1 in 2 month,4 month,6 month and 8 month thymus were detected by real-time PCR and Western-blot.At the same time,the changes of FoxN1 expression in Minzhu and Large white pig after cold stress were also detected.The results showed that FoxN1 expression level reached the highest level in 4 month,and declined in 6 month.This expression pattern is consistent with human and mouse.Cold stress could rise the expression level of Minzhu FoxN1,while have no effect on the Large white pig.
