Clinical Effect of Febuxosta on the Patients with Primary Gout Complicated with Mild to Moderate Renal Insufficiency
10.13241/j.cnki.pmb.2017.26.034
- VernacularTitle:非布司他治疗原发性痛风合并轻中度肾功能不全的临床疗效
- Author:
Jie GENG
;
Qian WU
;
Wenyan YANG
;
Chao XU
;
Baikui ZHANG
- Keywords:
Febuxosta;
Primary gout;
Mild to moderate renal insufficiency;
Curative effect;
safety
- From:
Progress in Modern Biomedicine
2017;17(26):5149-5152
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the curative effect and safety of febuxosta for the patients with primary gout complicated with mild to moderate renal insufficiency.Methods:60 male patients with primary gout complicated with mild to moderate renal insufficiency were enrolled in the affiliated Hospital of integrated traditional Chinese and Westem Medicine,Nanjing University of Chinese Medicine from January 2015 to August 2016 and randomly divided into two groups,the control group (n=30) was treated by allopurinol,and the study group (n=30) was treated by febuxosta treatment.The blood uric acid (BUA) and hepatorenal function were compared in the treatment period,and the incidence of adverse reactions and the recurrence of gout in post-treatment were compared.Results:At 1,2 and 3 month after treatment,the serum level of BUN in the study group was significantly lower than that of the control group (P＜0.05).The renal function of all patients were significantly improved compared with pre-treatment (P＜0.05),but the no significant difference was found between two groups at the same time(P＞0.05).The control group showed the adverse reactions with limb discomfort,drowsiness,nausea,abdominal distension,diarrhea and itch of skin,and the study group showed limb discomfort,drowsiness and abdominal distension,and one patients presenting allergic skin rash and discontinuation of allopurinol.The total incidence of adverse reactions in the study group was significantly lower than that of the control group (P＜0.05).Conclusions:Febuxosta could effectively and safely decrease the blood uric acid levels and improve the renal function of patients with primary gout complicated with mild to moderate renal insufficiency.
