Calponin Isoforms and Biological Functions
10.13241/j.cnki.pmb.2017.26.043
- VernacularTitle:类肌钙蛋白(Calponin)亚型和生物学功能
- Author:
Yu WU
;
Rong LIU
;
Jianping JIN
- Keywords:
Calponin;
Isoform;
Protein structure;
Cell biological function;
Cancer
- From:
Progress in Modern Biomedicine
2017;17(26):5185-5188
- CountryChina
- Language:Chinese
-
Abstract:
Calponin is an actin filament-associated regulatory protein expressed in smooth muscle and many types ofnonmuscle cells.Three calponin isoforms 1,2,and 3 are encoded by three homologous genes CNN1,CNN2 and CNN3 in vertebrate species with cell type-specific expression and functions.Besides modulating the activity of smooth muscle myofilaments and contractility,calponin also regulates the functions of actin cytoskeleton in non-muscle cells during cell proliferation,adhesion,migration,differentiation,phagocytosis and fusion.This review focuses on the evolution,tissue and cell type-specific expression,structure-function relationships,transcriptional regulation and relevant mechanisms.
