Effect of Early Mother-to-child Isolation on Neuronal Cell Apoptosis in Neonatal Mice
10.13241/j.cnki.pmb.2017.26.007
- VernacularTitle:出生早期母婴分离对新生小鼠神经元细胞凋亡的影响
- Author:
Haipeng YANG
;
Liwei WANG
;
Qingliang SHAO
;
Yue GAO
;
Xuan ZHAO
;
Xuehua QU
- Keywords:
Newborns;
Maternal and child separation;
Nervous system
- From:
Progress in Modern Biomedicine
2017;17(26):5034-5037
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effect of early mother to child separation on neonatal nervous system and its related mechanism.Methods:Randomly selected during January 2015 to September 2015,was born in 120 cases of newborn mice as the research object,the newborn mice was born after the implemented of mother-to-child separation as observation group (60),not the implemented of separation of mother and baby after birth as the control group (60),in view of the two groups of newborn mice of the nervous system,the change of the nerve cells were compared and researched.Results:The apoptotic rate of neurons in the neonatal mice was significantly higher than that in the control group (P ＜0.05).The neurons of caspase-3 protein expression was significantly higher than the control group (P ＜0.05).The expression of Caveo-1 protein in the glial cells of 14 days and 21 days was observed in the neonatal mice.The expression of Caveo-1 protein in the glial cells of the control group For comparison,(P ＜0.05),which were statistically significant.Conclusion:The early implementation of matemal and infant birth separation of neonatal nervous system will produce great influence,and influence the expression of the nervous system in the development of newborn,which affect the behavior of the neonatal adult dysplasia.
