Research process on the virulence factors of Gallibacterium anatis in poultry
10.16303/j.cnki.1005-4545.2017.08.35
- VernacularTitle:鸭源鸡杆菌相关致病因子研究进展
- Author:
Jiyang WANG
;
Yan WANG
;
Zhifeng PENG
;
Xia YANG
- Keywords:
Gallibacterium anatis;
virulence factors;
research process
- From:
Chinese Journal of Veterinary Science
2017;37(8):1627-1632
- CountryChina
- Language:Chinese
-
Abstract:
Gallibacterium anatis,a member of the Pasteurellaceae family,constitutes a part of the normal micro-flora of the upper respiratory tract and the lower genital tract in chickens.However,increasing evidence indicate that G.anatis is also associated with a wide range of pathological changes,particularly in the reproductive organs,which leads to decreased egg production,lowered animal welfare and increased mortality.As a recently defined opportunistic pathogen limited focus has been placed on the pathogenesis and putative virulence factors permitting G.anatis to cause disease.One of the most studied virulence determinants is a large RTX-like toxin (GtxA),which has been demonstrated to induce a strong leukotoxic effect on avian macrophages.A number of fimbria of different sizes and shapes,particularly the F17-1ike fimbriaes,appear to be common in a diverse selection of G.anatis strains.The capsular material expressed possibly involved in serum resistance,metalloproteases capable of degrading immunoglobulins,hemagglutinins,and all factors which may promote biofilm formation are likely linked to the virulence of G.anatis.This review summarized the putative virulence factors described for this bacterium to date.
