Correlation of the Serum Levels of Adiponectin, IGF-Ⅰ, PA with EUGR in Preterm Infants
10.13241/j.cnki.pmb.2017.26.028
- VernacularTitle:脂联素、胰岛素生长因子-Ⅰ、前清蛋白与早产儿宫外发育缓慢的相关性
- Author:
Fuli JIN
;
Hongxia SONG
;
Wenping SONG
;
Li ZHANG
;
Xiaoling BAO
- Keywords:
EUGR;
Preterm infants;
Adiponectin;
IGF-Ⅰ;
PA
- From:
Progress in Modern Biomedicine
2017;17(26):5128-5130,5180
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the levels of serum adiponectin,insulin growth factor Ⅰ (IGF-Ⅰ) and prealbumin in preterm infants,and analyze their correlation with preterm EUGR infant.Methods:321 cases of preterm infants who were born in our hospital and transferred to neonatal department in 24 hours from January,2014 to January,2016 were enrolled in the present study.According to the weight at discharge,they were divided into the EUGR group and the non EUGR group,the growth and development as well as the levels of serum adiponectin,IGF-Ⅰ and PA in the two groups were compared.Results:The occurrence rate of EUGR was 55.76％ (179/321) in the 321 cases ofpreterm infants;the weight of EUGR group was significantly lower than that of the non EUGR group at 42 th days and three months after birth(p＜0.05).The SDS of both groups were all negative,and that of EUGR group was significantly lower than non EUGR group (p＜0.05).The levels of serum adiponectin,IGF-Ⅰ and PA of both groups were significantly lower than the control group at seventh days of birth,and the PA level of EUGR group was significantly lower than non EUGR group (p＜0.05).There was no significant difference in the serum adiponectin and PA levels between 7 days and 14 days in EUGR group (P ＞ 0.05),however,the serum adiponectin and PA levels in the non EUGR group was obviously increased and significantly higher than that of the EUGR group (p ＜ 0.05).The level of IGF-Ⅰ in both groups keep unchanged during two weeks (P＞0.05).Conclusion:The lower levels of serum adiponectin,IGF-Ⅰ and PA were closely related to the EUGR of preterm infants,which could be used as biochemical indexes to early diagnosis of EUGR.
