Effect of Post-conditioning in Brain Injury Induced by Myocardial IR on Inflammatory Factor and GFAP
10.13241/j.cnki.pmb.2017.27.002
- VernacularTitle:后处理对心肌缺血再灌注致脑损伤中炎症因子及GFAP的影响
- Author:
Lian LIU
;
Zhongyuan XIA
;
Quan YUAN
;
Bo ZHAO
;
Meng JIANG
- Keywords:
Post-conditioning;
Myocardial ischemia reperfusion;
Inflammatory factor;
GFAP
- From:
Progress in Modern Biomedicine
2017;17(27):5206-5209
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effect of post-conditioning in brain injury induced by myocardial I/R on inflammatory factor and GFAP.Methods:Male Sprague-Dawley rats were randomly allocated into 3 groups (n=8):group Sham,group IR,group IPost.Myocardial IR was induced by occlusion of the anterior descending branch of the left coronary artery for 30 min.group IPost received 3 cycles of 10 s reperfusion followed by 10 s ischemia at the end of myocardial ischemia.The rats were sacrificed at 120 rain of reperfusion and the brains were removed for microscopic examination,inflammatory factors and GFAP.Results:Compared with group Sham,IL-6,IL-8 were significantly increased,IL-10 was down-regulated in group IR(P＜0.01).Post-conditioning can decrease IL-6,IL-8 and up-regulated IL-10(P＜0.01).When compared with group Sham,the expression of GFAP was higher in group IR(P＜0.05),however,the GFAP in group IPost is the most among these three groups(P＜0.01).Conclusion:Post-conditioning could protect brain by decreasing inflammatory factors,increasing GFAP,which both from brain injury induced by myocardial ischemia reperfusion.
