Cytokine genetic polymorphisms in Kawasaki disease combined with coronary artery lesions
10.3760/cma.j.issn.1673-4408.2017.08.001
- VernacularTitle:川崎病冠状动脉病变相关细胞因子基因多态性
- Author:
Sirui SONG
- Keywords:
Kawasaki disease;
Coronary artery lesion;
Cytokine;
Gene polymorphism
- From:
International Journal of Pediatrics
2017;44(8):515-518
- CountryChina
- Language:Chinese
-
Abstract:
Kawasaki disease(KD) is an acute febrile childhood inflammatory disease,characterized by systemic small artery inflammation as the main pathological changes that can lead to expansion of coronary artery,myocardial infarction and sudden cardiac death.Cytokines secreted by immune cells are small molecules,which can regulate the function of inflammatory cells,play important roles in the process of immune response,stimulate the proliferation and differentiation of cells,and regulate interactions between them.In the acute phase,super antigens activate immune responses.A large number of cytokines and inflammatory mediators are released into the blood,which participate in the occurrence and development of KD and the vascular disease.Many inflammatory cytokines are associated with coronary artery damages in KD patients.In this paper,the roles of various cytokines in the coronary artery lesions of KD are reviewed.
