Clinical Effect of Abdominal Total Hysterectomy on Uterine Fibroids and Serum VEGF, IL-6 and IL-8 Levels
10.13241/j.cnki.pmb.2017.27.018
- VernacularTitle:经腹次全子宫切除术治疗子宫肌瘤的临床效果及对血清VEGF,IL-6,IL-8水平的影响
- Author:
Zhangxia CUI
;
Miao DANG
;
Yongkang YANG
;
Xiaocai ZHANG
;
Jing YANG
- Keywords:
Uterine fibroids;
Abdominal total hysterectomy;
Vascular endothelial growth factor;
Interleukin-6;
Interleukin-8
- From:
Progress in Modern Biomedicine
2017;17(27):5275-5278
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To research the clinical effect of abdominal total hysterectomy on the patients with uterine fibroids and the serum vascular endothelial growth factor (VEGF) and interleukin 6 (IL-6),interleukin 8 (IL-8) levels.Methods:106 cases of patients with uterine fibroids from February 2014 to February 2016 were divided into the control group and the research group according to the lottery method,the control group was treated with total abdominal hysterectomy,while the research group was given abdominal total hysterectomy treatment,the operation time,blood loss,anal exhaust time,length of hospital stay,changes of serum VEGF,IL-6,IL-8,Follicle stimulating hormone (FSH),estradiol (E2) levels,resistance to seedling le tube hormone (AMH) before and after the surgery as well as the occurrence of complications were compared between two groups.Results:The operation time,blood loss,length of hospital stay,anal exhaust time of research group were significantly shorter than those of the control group (P＜0.05).Before surgery,the serum levels of VEGF,IL-6,IL-8,FSH,E2,AMH showed no difference between two groups (P＞0.05).After the operation,the serum levels of IL-6,IL-8,E2,AMH of research group were lower than those of the control group (P＜0.05),the serum level of FSH in research group was higher than that of the control group (P＜0.05).The serum level of VEGF showed no difference between the two groups (P＞0.05).The incidence rate of complications in research group was lower than that of the control group (P＜0.05).Conclusion:Abdominal total hysterectomy showed similar effect with the abdominal hysterectomy in the treatment of uterine fibroids patients,but the abdominal full hysterectomy induced less trauma,promoted the recovery of ovarian function after surgery,which might be related to the decrease of serum IL-6,IL-8 and VEGF levels.
