Effect of Flurbiprofen Compound Small Dose Fentanyl on Intravenous Analgesia and Blood Coagulation Function of Patients with Laparoscopic Cholecystectomy
10.13241/j.cnki.pmb.2017.26.042
- VernacularTitle:氟比洛芬酯复合小剂量芬太尼对腹腔镜胆囊切除术患者镇痛效果及凝血功能的影响
- Author:
Ye LU
;
Suqin MIAO
;
Dezhen LV
;
Lulu SU
;
Hong GAO
- Keywords:
Laparoscopic cholecystectomy;
Flurbiprofen ester;
Small dose fentanyl;
Venous self-control analgesia;
Coagulation function
- From:
Progress in Modern Biomedicine
2017;17(26):5181-5184
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To research the application of flurbiprofen compound small dose fentanyl with self-control vein analgesia after laparoscopic cholecystectomy and the influence on blood coagulation function.Methods:102 cases with laparoscopic cholecystectomy who were treated in our hospital from November 2015 to November 2016 were selected and divided into the control group and the research group,with 51 cases in each group.The patients in the control group were treated with postoperative intravenous analgesia with low-dose fentanyl,while the patients in the research group were treated with postoperative intravenous analgesia with flurbiprofen ester compound low-dose fentanyl.Then the fibrinogen (Fg),activated partial prothrombin time (APTT),prothrombin time (PT),platelet count (PLT),substance P,5-hydrocarbon serotonin (5-HT),interleukin 6,8 (IL-6,IL-8) and complications between two groups were observed and compared.Results:Before treatment,there was no statistically significant difference about the Fg,APTT,PT,PLT,substance P,5-HT,IL-6 and IL-8 between two groups (P＞0.05);After treatment,the Fg,APTT,PT,PLT,substance P,5-HT,IL-6 and IL-8 increased in the two groups,while the research group was lower than that of the control group,and the differences were statistically significant (P＜0.05).The postoperative complication rate of research group was lower than that of the control group (P＜0.05).Conclusion:Flurbiprofen ester compound small dose fentanyl with self-control vein analgesia can relieve coagulation function,and inhibit the levels of inflammatory factors.
