Prognostic Significance of Plasma Fibrinogen and D-dimer in Elderly Patients with NSCLC
10.13241/j.cnki.pmb.2017.27.015
- VernacularTitle:血浆纤维蛋白原和D-二聚体在老年NSCLC患者预后中的意义
- Author:
Hengqiong GU
;
Xin SU
;
Xuanhao WU
;
Yongfeng FU
;
Yang XU
- Keywords:
Fibrinogen;
D-dimer;
Non-small cell lung cancer;
Prognosis
- From:
Progress in Modern Biomedicine
2017;17(27):5262-5266
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the prognostic significance of plasma fibrinogen (FIB) and D-dimer in elderly patients with non-small cell lung cancer (NSCLC) before any anti-cancer treatments.Methods:97 cases of patients with lung cancer (lung cancer group) and 36 healthy subjects (control group) were enrolled;the level of plasma D-dimer and FIB were compared;the relationship between their levels and clinical pathological factors of NSCLC as well as prognosis was analyzed.Results:The levels of plasma FIB and D-dimer in lung cancer group were higher than those in healthy control group (P＜0.05).FIB in lung cancer group was related to TNM stage,and D-dimer was related to lymph node metastasis and TNM stage.Univariate analysis showed that FIB,D-dimer,tumor size,lymph node metastasis and TNM staging were associated with overall survival time (OS) and progression free survival (PFS).Multivariate analysis revealed that only D-dimer and FIB were independent prognostic factors of patients with NSCLC.Conclusion:Detection of fibrinogen and D-dimer in elderly patients with NSCLC before anti-cancer treatment would be useful for prognosis and might provide a certain value for individualized therapy.
