Progress on the mechanism of iron overload in myelodysplastic syndrom
10.3760/cma.j.issn.1673-4408.2017.08.010
- VernacularTitle:骨髓增生异常综合征铁超载机制的研究进展
- Author:
Chunlei ZHANG
- Keywords:
Myelodysplastic syndrome;
Hepcidin;
Transfusion dependence;
Iron overload
- From:
International Journal of Pediatrics
2017;44(8):551-553
- CountryChina
- Language:Chinese
-
Abstract:
Myelodysplastic syndrome (MDS) is a group of origin of hematopoietic stem/progenitor cells of myeloid clonal disorders.Studies have shown that MDS patients are with varying degrees of abnormal iron metabolism in the course of diagnosis and supportive care.Iron overload can damage the body's iron balance.Excess free iron can sink in plasma and tissue,especially in the body's major organs such as heart,liver and endocrine gland,resulting in structural damage and organ dysfunction,accelerating transformation to acute myeloid leukemia,and increasing the death rate.Iron chelation can improve the prognosis of patients,prolong overall survival and leukemia-free survival.The mechanism of iron overload in MDS research will be described in this paper.
