Advances in nervous system complications and intervention of human and rats anorectal malformation

VernacularTitle:肛门直肠畸形人类及大鼠神经系统的并发症及神经支配研究进展
Author: Zhonghua YANG ; Linlin GAO ; Yuanyuan GENG
Keywords: Anorectal malformation; Nervous system
From: International Journal of Pediatrics 2017;44(8):554-558
CountryChina
Language:Chinese
Abstract: Anorectal malformations (ARM)comprise a broad spectrum of congenital disorders that account for 25 ％ of gastrointestinal malformations.Despite numerous technical advances for treatment of ARM,complications such as fecal incontinence and constipation still occur and can greatly deteriorate patients' quality of life.It is recognized that lumbosacral spinal cord anomalies in ARM has been an important factor affecting the fecal function after procedure.Researchers have found that lumbosacral myelodysplasia is the common seen complication of ARM and neural cells decreased in lumbosacral spinal cord by the study on animals and human.Due to numerous factos affecting nerve innervation on annrectus and pelvic floor muscle,this review summarizes the nervous system complications and abnormal intervention of human and rats ARMs.The developments of study on ARM complications and intervention are detailed.Then the new direction of the research about the anorectal malformation nervous system is put forward,and the new strategy of improving the prognosis of anorectal malformation surgery is explored.