Analysis of the Causes of Total Fertilization Failure in Vitro Fertilization-Embryo Transfer
10.13241/j.cnki.pmb.2017.27.048
- VernacularTitle:体外受精-胚胎移植中完全受精失败的原因分析
- Author:
Jing DAI
;
Zenghui HUANG
;
Shuoping ZHANG
;
Changfu LU
;
Ge LIN
- Keywords:
Total fertilization failure;
In vitro fertilization;
Zona pellucida;
Intracytoplasmic sperm injection
- From:Progress in Modern Biomedicine
2017;17(27):5389-5391,5395
- CountryChina
- Language:Chinese
-
Abstract:
Fertilization is a crucial step for origin of life.During Assisted Reproductive Technologies (ART),total fertilization failure is complex and unpredictable.Total fertilization failure may related to some abnormal cellular mechanistic events,such as:any stage of sperm and cumulus-oocyte-complexes penetration,sperm-zona pellucida binding / penetration,sperm-oocyte membrane binding,oocyte activation,sperm discondensation or pronuclear formation.Most of total fertilization failure could be solved by intracytoplasmic sperm injection.But oocytes of some patient still can't fertilize successfully,even though assisted oocyte activation be used.As for total fertilization failure patients in ART,combining the mature of oocyte,sperm quality and some trail to improve clinical protocol in later cycle may prevent failure to happen again.
