The Research Progress of Metformin in Type Ⅱ Diabetes Mellitus with Liver Cancer
10.13241/j.cnki.pmb.2017.27.049
- VernacularTitle:二甲双胍在Ⅱ型糖尿病合并肝癌中的研究进展
- Author:
Mingcheng LI
;
Huawei SU
;
Zhanli PENG
;
Zhen MA
;
Yuwei REN
- Keywords:
Liver cancer;
Metformin;
Type 2 diabetes;
Therapy
- From:
Progress in Modern Biomedicine
2017;17(27):5392-5395
- CountryChina
- Language:Chinese
-
Abstract:
As a safe,cheap and effective diabetes drug,metformin has been used for many years.Diabetes increases the risk of liver cancer and affects its prognosis.In recent years,it is found that metformin reduces the pancreatic cancer risk in the treatment of diabetic patients,a large of experiments also prove that it has anti-cancer and synergistic anticancer effect.This paper focused on the effects of metformin on treatment of Ⅱ type diabetes,discussed the curative effect on liver cancer,suggested the molecular biology mechanism of inhibiting tumor,listed the latest experiment researches,analyzed the existed clinical data,proposed the further study of anticancer mechanism and clinical treatment.Metformin for a future role in prevention of hepatocellular carcinoma in patients with type Ⅱ diabetes are briefly summarized and future prospects,which in type Ⅱ diabetic patients with liver cancer in a prospective study of the effect of treatment.Mefformin for application in other cancer prevention also raises possibilities.
