Effect of Naoxintong Capsule Combined with Nerve Growth Factor in Treatment of Hypertensive Cerebral Hemorrhage and Its Effect on Serum Levels of IL-6, MMP-9 and S 100B
10.13241/j.cnki.pmb.2017.25.036
- VernacularTitle:脑心通胶囊联合神经生长因子治疗高血压脑出血的疗效及对血清IL-6、MMP-9、S100B水平的影响
- Author:
Li ZHONG
;
Li CHEN
;
Peng TANG
;
Peng LIU
;
Yue LIU
- Keywords:
Naoxintong capsule;
Nerve growth factor;
Hypertensive intracerebral hemorrhage;
Serum interleukin-6;
Matrix metalloproteinase-9;
S100B
- From:
Progress in Modern Biomedicine
2017;17(25):4948-4951
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the effect of naoxintong capsules combined with nerve growth factor on the serum levels of interleukin-6 (IL-6),matrix metalloproteinase-9 (MMP-9) and S100B of patients with hypertensive intracerebral hemorrhage.Methods:88 patients with hypertensive intracerebral hemorrhage who were treated in our hospital from August 2015 to July 2016 were selected and randomly divided into the observation group and the control group The patients in the control group were treated with nerve growth factor,while the patients in the observation group were treated with naoxintong capsules combined with nerve growth factor.Then the clinical efficacy,GCS,GOS score,serum levels ofIL-6,MMP-9 and S100B were observed and compared between the two groups.Results:After treatment,the total effective rate in the observation group was significantly higher than that the control group (P＜0.05).After treatment,the GCS and GOS scores of the two groups were significantly higher than before,and the GCS and GOS of the observation group were higher than those of the control group (P＜0.05).After treatment,the serum levels of IL-6,MMP-9 and S100B in the two groups were significantly lower than before,and the observation group were lower than those of the control group (P＜0.05).There was adverse reactions in the two groups.Conclusion:Naoxintong capsule combined with nerve growth factor can reduce the serum levels of IL-6,MMP-9 and S100B in patients with hypertensive intracerebral hemorrhage,with obvious clinical curative effect and high safety.
