Clinical Efficacy of Topiramate, Carbamazepine and Sodium Valproate in the Treatment of Epilepsy Secondary to Encephalitis
10.13241/j.cnki.pmb.2017.25.038
- VernacularTitle:托吡酯、卡马西平与丙戊酸钠治疗脑炎继发癫痫的疗效比较
- Author:
Jie YUAN
;
Dan CHEN
;
Hong LI
;
Hong ZHANG
;
Shuqi YU
- Keywords:
Topiramate;
Carbamazepine;
Sodium valproate;
Epilepsy secondary to encephalitis;
Cognitive function
- From:
Progress in Modern Biomedicine
2017;17(25):4956-4958,4989
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe and compare the clinical curative effect and safety of topiramate,carbamazepine and sodium valproate on the epilepsy secondary to encephalitis.Methods:80 cases of patients with epilepsy secondary to encephalitis who were treated in our hospital from January 2010 to September 2015 were selected and divided into the topiramate group,carbamazepine group and sodium valproate group,which were treated with topiramate,carbamazepine and sodium valproate respectively.The treatment effect,congnitive scores (including executive function and visual space,name,language,abstract,attention,delayed memory,directional),adverse reaction rate of three groups were compared.Results:The effective rate oftopiramate group was the highest(80.65％,25/31),carbamazepine was the lowest (70.00％,21/30),but there was no significant difference between the three groups (P＞0.05).After treatment,the scores of executive ability and visual spatial,naming,abstraction,attention,orientation,language in topiramate group were significantly higher than those of carbamazepine group and sodium valproate group (P＜0.05);the incidence of adverse reactions of topiramate group was 12.90％,which was significantly lower than that of carbamazepine group (36.67％) and sodium valproate group (29.62％)(P ＜ 0.05).Conclusions:Topiramate,carbamazepine and sodium valproate have equal therapeutic effect on epilepsy secondary to encephalitis,but topiramate had less adverse reactions and best safety.
