The Progress in the Animal Modeling of Pulmonary Arterial Hypertension
10.13241/j.cnki.pmb.2017.25.044
- VernacularTitle:肺动脉高压动物模型的相关研究进展
- Author:
Jie LUO
;
Ling ZHOU
;
Xiaomin JIANG
;
Peng YE
;
Shaoliang CHEN
- Keywords:
Animal model;
Pulmonary arterial hypertension;
Monocrotaline;
Chronic hypoxia
- From:
Progress in Modern Biomedicine
2017;17(25):4979-4981,4978
- CountryChina
- Language:Chinese
-
Abstract:
Animal models of pulmonary artery hypertension (PAH),aiming to simulate human characteristics of the disease,have contributed extensively to understanding the pathophysiology of PAH and the investigation of experimental treatments.The classical models include monocrotaline models,chronic hypoxia model and so on,more new models were investigated in recent years.These animal models were not able to perfectly mimic human pathological characteristics of PAH because of the defect in different aspects.In this review,both typical and novel methods of PAH modeling were summarized and evaluated to provide a suitable guidance for the settlement of animal models which can meet human characteristics comprehensively.
