Research Progression on Mechanism of Liver Injury Induced by Heatstroke
10.13241/j.cnki.pmb.2017.25.049
- VernacularTitle:中暑致肝损伤机制的研究进展
- Author:
Xiangxin YANG
;
Liang XIA
;
Jiangwei LIU
;
Caifu SHEN
;
Rong ZHAO
;
Qin XU
- Keywords:
Heatstroke;
Liver injury;
Energy metabolism;
Inflammation
- From:
Progress in Modern Biomedicine
2017;17(25):4997-5000
- CountryChina
- Language:Chinese
-
Abstract:
Heatstroke is a critical disease which usually catches in the hot environment in summer and abundant exercise that could bring about multiple organ dysfunction.The process of the occurrence and development of heatstroke includes of the compensatory phase,acute reaction stage and decompensation stage.The recent researches have shown that the mechanism of liver injury induced by heatstroke might be related to the direct action of heat,mitochondrial dysfunction in liver cells and cascade of inflammatory response,and each link promoted each other,finally caused liver injury.In addition,a cascade of inflammatory responses in the hepatic sinusoid might play a predominant role in liver injury induced by heatstroke.This paper aims to review the mechanism of liver damage caused by heatstroke in terms of the physiology and pathology,so as to provide perspectives for clinical prevention and treatment of liver injury.
