Interleukin-27 Enhances TNF-α-mediated Upregulation of Inflammatory Cytokine and Chemokine
10.13241/j.cnki.pmb.2017.23.003
- VernacularTitle:IL-27增强TNF-α介导上调的炎症因子的表达
- Author:
Huaina QIU
;
Hefei ZHA
;
Jiale QU
;
Mei WANG
;
Yuanfa FENG
;
Jun HUANG
;
Quan YANG
- Keywords:
Vascular inflammation;
Cytokine;
Chemokine;
Human coronary artery endothelial cells
- From:
Progress in Modern Biomedicine
2017;17(23):4412-4415
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Immune cells and inflammatory mediators play important roles in the development of atherosclerotic vascular inflammation.This study focuses on the direct effect ofIL-27 on human coronary artery endothelial cells.Methods:In this study,the effects of IL-27 and TNF-α on inflammatory cytokines and chemokines were investigated.Results:IL-27 could significantly enhance the TNF-α-mediated upregulation of inflammatory cytokine IL-6 and chemokines CCL5 from human coronary artery endothelial cells.The release of IL-6 and CCL5 was significantly suppressed by specific signaling molecule inhibitors.Conclusion:The induction of these mediators from the human coronary artery endothelial cells could be differentially regulated by the c-Jun N-terminal kinase,p38 mitogen-activated protein kinase,and nuclear factor-κB pathways.These results provided new insights into the effect of IL-27 on the TNF-α mediated activation of human coronary artery endothelial cells in atherosclerotic vascular inflammation.
