Observation on the Clinical Effect of Seretide and Noninvasive Positive Pressure Ventilation on the COPD Combined with Respiratory Failure
10.13241/j.cnki.pmb.2017.23.018
- VernacularTitle:舒利迭联合无创正压通气治疗COPD合并呼吸衰竭的临床疗效观察
- Author:
Wenli CHU
;
Liqiang SONG
;
Ruina YAN
;
Huifang WANG
;
Panxia NIU
;
Li ZHOU
- Keywords:
Chronic obstructive pulmonary disease;
Type 2 respiratory failure;
Seretide;
Noninvasive positive pressure ventilation;
Efficacy
- From:Progress in Modern Biomedicine
2017;17(23):4483-4486,4540
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the clinical efficacy of Seretide combined with noninvasive positive pressure ventilation (NIPPV) in the treatment of chronic obstructive pulmonary disease (COPD) complicated with type 2 respiratory failure (RF).Methods:120 patients of COPD complicated with type 2 RF were randomly divided into the observation group and the control group.All patients were treated with routine,symptomatic and supportive treatment,based on that NIPPV was used in the control group,and the observation group was treated with Seretide on the basis of NIPPV.The levels of arterial blood gas,inflammatory factors,pulmonary function and CAPS score before and after treatment were compared and analyzed.Results:After treatment,the pH,PaO2 and SaO2 of both groups were significantly increased,PaCO2 levels weresignificantly decreased,serum IL-33,TNF-oα and sICAM-1 levels were significantly decreased,FVC,PEFR,FEV1％ and FEV1/FVC were significantly decreased,and the CAPS scores were significantly decreased;the changes of all the index mentioned above in the observation group were more statistically significant (P＜0.05).Conclusion:Seretide com bined with NIPPV could more effectively decrease the levels of inflammatory factors and improve the blood gas and lung function in the patients of COPD with type 2 respiratory failure.
