EGFR Mutation Status among NSCLCs in Southern Shaanxi
10.13241/j.cnki.pmb.2017.25.010
- VernacularTitle:陕西省南部地区非小细胞肺癌EGFR基因突变分析
- Author:
Hongwei LI
;
Xuemei XING
;
Guoyin LI
;
Mingxing WANG
;
Jinbo ZHAO
;
Xiaofei LI
;
Yong HAN
- Keywords:
Non-small cell lung cancer;
Gene mutation;
Demographic distribution;
Regional differences;
Epidermal growth factor receptor
- From:
Progress in Modern Biomedicine
2017;17(25):4842-4846
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the EGFR gene polymorphism in the non-small cell lung (NSCLCs) cancer in southern of Shaanxi Province.Methods:The next generation sequencing technology was used to detect the mutation of exon 18,19,20 and 21 of EGFR gene.We analyzed EGFR gene mutation rate in NSCLCs patients.233 patients was involved in our study.Results:82 cases with EGFR gene mutations was found,the mutation rate of exon18,19,20 and 21 was 1.3％,16.3％,0％ and 18％ respectively.The mutation rate of EGFR in male patients was lower (31.2％,39/125) than that of female cases (39.8％,43/108),the mutation rate of squamous cell carcinoma (22％,9/41) was lower than that of adenocarcinoma (39.1％,75/192).Conclusions:NSCLCs patients from southern Shaanxi Province had high mutation rate ofEGFR gene,and exon 19 and exon 21 mutations were in the majority.EGFR gene mutation rate was not related to gender and pathological types.
