Correlation between Lung Function and Peripheral Interleukin Expression of Mycoplasma Pneumonia Children
10.13241/j.cnki.pmb.2017.25.017
- VernacularTitle:肺炎支原体肺炎患儿外周血白介素的表达与肺功能变化的相关性
- Author:
Yuelin DENG
;
Xiaoting YU
;
Ling LI
;
Xiaoli XU
;
Xin SUN
;
Hongyang SHI
- Keywords:
Mycoplasma pneumoniae pneumonia;
IL-10;
IL-17;
Pulmonary Function
- From:
Progress in Modern Biomedicine
2017;17(25):4873-4875
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation between IL-10 and I1-17 expression levels in Mycoplasma pneumoniae pneumonia (MPP) and lung function.Methods:70 patients were included in this study.According to wheezing or not,they were divided into wheezing group and non-wheezing group.Another 30 healthy children were taken as a control group.After taking fasting blood 5ml,the serum IL-10 and IL-17 expression levels were detected by ELISA.The forced expiratory volume in one second (PEV1),peak expiratory flow (PEF) and forced vital capacity (FEV1 / FVC) of all subjects were detected.Results:The IL-10 expression level of the wheezing group were significantly different with that of the control group (P＜0.05) and that of the non-wheezing group (P＜0.05).The 1L-17 expression level of the wheezing group also had significant difference (P＜0.05) with that of the control group and non-wheezing group (P＜0.05).The IL-10 expression levels of wheezing and non-wheezing group all were lower than that of the control group.Whereas the IL-17 expression levels of wheezing and non-wheezing group all were higher than that in the control group.In addition,patients in wheezing group had higher PEV1,PEF,PVE1/FVC values than those in non-wheezing group,with significant difference (P＜0.05).The serum level of IL-10 expression of Mycoplasma pneumonia patients was positively correlated with PEV1,PEF and PVE1/FVC,while the serum level of IL-17 expression of Mycoplasma pneumonia patients was negatively correlated with PEV1,PEF and PVE1/FVC.Conclusion:The serum levels of IL-17 and IL-10 expression of Mycoplasma pneumonia children had close correlation with their pulmonary function.
