Clinical Effects of Tacrolimus Combined with Okra Capsule in Treatment of Refractory Membranous Nephropathy
10.13241/j.cnki.pmb.2017.25.019
- VernacularTitle:他克莫司联合黄葵胶囊治疗难治性膜性肾病的临床疗效
- Author:
Xiaohui YAN
;
Yan LIANG
;
Ting FENG
;
Gang JIN
;
Xiaoming WANG
- Keywords:
Tacrolimus;
Okra capsules;
Membranous nephropathy;
Refractory
- From:
Progress in Modern Biomedicine
2017;17(25):4880-4882,4899
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect and safety of tacrolimus combined with Okra capsule in treatment of the refractory membranous nephropathy.Methods:Selected 60 patients with refiactory membranous nephropathy who were treated in our hospital from March 2014 to October 2015,and they were divided into observation group and control group with 30 cases in each group according to the random number table method.The control group was treated with prednisone,and the observation group was treated with tacrolimus combined with Okra capsule on the basis of the control group,the courses of treatment were 6 months in two groups.The clinical effects were observed in two groups,the levels of urine protein (uPRO),serum Albumin (sALB),serum Creatinine (sCr),serum Alanine aminotransferase (sALT),tumor necrosis factor-α (TNF-α) and transforming growth factor-β 1 (TGF-β1) were detected and compared in two groups before and after treatment,and the adverse reactions were recorded in two groups.Results:The total effective rate of the ob-servation group was significantly higher than control group (P＜0.05).Compared with before treatment,the levels ofuPRO,TNF-α,TGF-β1 in two groups were decreased after treatment,while sALB,sCr were increased (P＜0.05),and uPRO,TNF-o,TGF-β1 in the observation group were lower than the control group (P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups (P＞0.05).Conclusion:Tacrolimus combined with Huangkui capsule in the treatment ofrefractory membranous nephropathy has good curative effect,reduce renal damage,and low adverse reaction,worthy of promotion.
