Clinical Observation on Efficacy of Ulinastatin in Treatment of Sepsis Induced Acute Renal Injury
10.13241/j.cnki.pmb.2017.23.030
- VernacularTitle:乌司他丁对脓毒症急性肾损伤的临床疗效观察
- Author:
Bo CHEN
;
Min QIU
;
Dongjing RONG
;
Ting WANG
;
Yuqiong YANG
;
Hongyun BAO
;
Yang ZHANG
- Keywords:
Sepsis acute kidney injury;
Ulinastatin;
Urinary injury molecules-1;
Atrial natriuretic peptide;
Cyscatin-c
- From:
Progress in Modern Biomedicine
2017;17(23):4529-4532
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To research the clinical effects of ulinastatin in the treatment of sepsis induced acute renal injury and its possible mechanisms.Methods:114 cases of patients with sepsis induced acute kidney injury from 2014.02 ～ 2016.08 were selected and randomly divided into the control group (n=57) and experimental group (n=57) according to the draw method,the control group was given conventional treatment,while the experimental group was treated by ulinastatin based on the control group,the urine urinary injury molecule-1 (KIM-1),atrialnatriuretic peptide (ANP),cyscatin-c (CYS-C),interleukin l,6 (IL-1,IL-6),c-reactive protein (CRP),tumor necrosis factor-α(TNF-α),nitric oxide (NO),endothelin 1 (ET-1),immunoglobulin A,G,M (IgA,IgG,IgM) levels,APACHE-Ⅱ score were compared between two groups before and after the treatment.Results:After treatmented,the urine of KIM-1,ANP,serum of CYS-C,IL-l,IL-6,CRP,TNF-α,ET-1 levels and APACHE-Ⅱ score of experimental group were significantly lower than those of the control group (P＜0.05).The serum NO,IgA,IgG,IgM levels of experimental group were significantly higher than those of the control group (P＜0.05).Conclusion:Ulinastatin could significantly relieve sepsis induced acute renal injury,which might be related to the inhibition of inflammatory response,improvement of the renal blood flow and immune function.
