Advances of targeting heat shock protein 70 drugs
10.11665/j.issn.1000-5048.20170405
- VernacularTitle:以热休克蛋白HSP70为靶点的药物研究进展
- Author:
Zongliang LIU
;
Renmei ZHANG
;
Qingguo MENG
- Keywords:
HSP70;
function;
inhibitors;
agonists;
advances
- From:
Journal of China Pharmaceutical University
2017;48(4):416-424
- CountryChina
- Language:Chinese
-
Abstract:
Heat shock protein 70 (HSP70) family is one ofthe most conserved proteinin evolutionand plays critical,role in proteostasis.HSP70 is becoming an interesting target for multiple diseases such as cancer and Alzheimer's disease.There are many drugs targeted to HSP70 in preclinical study.In this review,the classification,the structure,the function of HSP70,and the drugs of the HSP70 family are reviewed.
