Synthesis and inhibition of NO production activities of 1,6-O, O-diacylbritannilactone derivatives
10.11665/j.issn.1000-5048.20170408
- VernacularTitle:1,6-O,O-二酰基大花旋覆花内酯衍生物的合成及其抑制NO生成活性
- Author:
Hong ZHU
;
Xiaopeng WEI
;
Meihua JIN
;
Nan QIN
- Keywords:
1,6-O,O-diacylbritannilactone;
derivatives;
synthesis;
nitrogen monoxide;
anti-inflammation activities
- From:
Journal of China Pharmaceutical University
2017;48(4):440-444
- CountryChina
- Language:Chinese
-
Abstract:
Eight 1,6-O,O-diacetylbritannilactone (OABL) derivatives (compounds 1-8) were synthesized by esterification or reduction of 1-O-diacetylbritannilactone (ABL) isolated from Inula japonica.All derivatives were evaluated for their anti-inflammation activities through the determination of inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced macrophages.As results,compounds 5-8 (IC50 ＜ 2 μmol/L) exhibited more potent inhibition of NO production activities than the lead compound OABL.
