Effect of Bronchoalveolar Lavage on the Inflammatory Mediators and Pulmonary Function of Patients with Refractory Pneumonia
10.13241/j.cnki.pmb.2017.23.035
- VernacularTitle:支气管镜下肺泡灌洗对难治性肺炎患者炎症介质和肺功能的影响
- Author:
Li ZHOU
;
Xudong CHENG
;
Ruina YAN
;
Yaowei WANG
;
Xue WANG
- Keywords:
Bronchoscopy;
Bronchoscope lavage;
Refractory pneumonia;
Inflammatory mediators;
Pulmonary function
- From:
Progress in Modern Biomedicine
2017;17(23):4549-4551
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the effect of bronchoscope lavage on the inflammatory mediators and pulmonary function of patients with refractory pneumonia.Methods:100 cases of patients with refractory pneumonia who were treated in our hospital from January 2010 to December 2015 were selected and randomly divided into two groups,the control group was treated with routine clinical treatment,and the observation group was treated with bronchoscope lavage.The curative effect and the changes of inflammatory mediators and pulmonary function of the two groups after treatment were compared.Results:After treatment,the effective rate of observation group was 90.00％(45/50),which was significantly higher than that of the control group (76.00％,38/50) (P＜0.05);the levels of endotoxin,IL-6,TNF-2 and LPO in the bronchoalveolar lavage fluid of both groups were significantly decreased (P＜0.05),which were decreased more significantly in the observation group (P＜0.05),the pulmonary function of both groups were significantly improved(P＜0.05),which improved more significantly in the observation group(P＜0.05).Conclusions:Bronchoscope lavage had good therapeutic effect on the patients with refractory pneumonia,it could effectively reduce the level of inflammatory mediators and improve the lung function.
