Recent advances in microglia activation and intervention mechanism in diabetic retinopathy
10.13389/j.cnki.rao.2017.0226
- VernacularTitle:糖尿病视网膜病变中视网膜小胶质细胞活化及干预机制研究进展
- Author:
Yue ZHANG
;
Ning DONG
- Keywords:
diabetic retinopathy;
microglia;
activation;
intervention
- From:
Recent Advances in Ophthalmology
2017;37(9):890-893
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic retinopathy (DR) is one of the most significant microvascular complications of diabetes,and its incidence increases with the prolongation of DM;meanwhile,it can lead to severe vision loss.Recently,the pathogenesis of DR has been one of the focuses both at home and abroad,but the basic mechanisms are not fully elucidated.More and more scholars believe that DR may be a chronic and low degree of inflammatory response.Moreover,it is well established that microglia is a monocyte-macrophage,with antigen-presenting function.Especially in the retina,as microglia is activated,followed by the release of a large number of inflammatory factors,microglia involves in DR inflammatory response.Understanding the activation mechanism of microglia can provide a new perspective for the prevention and treatment of DR.Therefore,recent advances in activation of microglia in diabetic retinopathy and its intervention mechanism will be reviewed in the article.
