Impact of left ventricular endocardial pacing on cardiac electrophysiology of canine asynchrony ischemic heart failure
10.3969/j.issn.1671-8348.2017.25.002
- VernacularTitle:左心室内膜起搏对犬失同步化缺血性心力衰竭心电生理的影响
- Author:
Rui DU
;
Ligang DING
;
Chuanyan ZHENG
;
Yuzhu LIU
- Keywords:
heart failure;
cardiac resynchronization therapy;
left ventricular endocardial pacing
- From:
Chongqing Medicine
2017;46(25):3460-3462
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the cardiac electrophysiology changes of canine asynchrony ischemic heart failure under left ventricular endocardial pacing.Methods Left bundle branch radiofrequency catheter ablation and left anterior descending coronary artery ligation were used to establish the model of ischemic heart failure in 18 healthy dogs.Eighteen healthy dogs were randomly divided into two groups,9 cases in each group.The experimental group was treated with cardiac resynchronization therapy(CRT) in left ventricular endocardium,and the control group underwent the sham operation.ECG and echocardiography were done at 6 weeks after operation.Results The left ventricular ejection fraction in the experimental group was significantly higher than that in the control group(38.32 ± 6.08 vs.30.62 ±8.96).The asynchronization index in the experimental group was significantly lower than that in the control group(35.99 ±5.25 vs.78.21 ± 7.02),and the difference was statistically significant(P＜0.05).QRS(60.58 ± 7.43 vs.68.33 ± 8.01) and QTc(347.09 ± 17.33 vs.367.81 ± 22.02)in the experimental group were significantly shorter than those in the control group(P＜0.05);moreover Tp-e(37.03±9.07 vs.45.76±7.11) and ARI(162.33±22.06 vs.187.21±23.87) in the experimental group were significantly lower than those in the control group(P＜0.05).Conclusion Left ventricular endocardial pacing can produce preferably electrophysiological effects and achieve the goal of effective cardiac resynchronization therapy.
