Effect of Qingqihuatan Decoction on pulmonary inflammation in asthmatic mouse
10.3969/j.issn.1671-8348.2017.25.006
- VernacularTitle:清气化痰汤对哮喘小鼠肺部炎症的影响
- Author:
Zhu CHEN
;
Yu PENG
;
Ping PANG
;
Jianhui YANG
;
Zhengqing LUO
- Keywords:
asthma;
inflammation;
Qingqihuatan Decoction
- From:
Chongqing Medicine
2017;46(25):3473-3476
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the interventional effect of Qingqihuatan Decoction on airway inflammation and inflammatory reaction of lung tissue in asthmatic mouse.Methods Forty-five BALB/c mice were randomly divided into the normal control group(CON),asthmatic model group(MOD),dexamethasone group(TRE),Qingqihuatan Decoction group(X1) and Qingqihuatan Decoction combined dexamethasone group(X2).The asthmatic mouse model was established by the sensitization and inhalation of OVA and aluminium hydroxide gel.The bronchoalveolar lavage fluid (BALF) was performed the cell counts and eosinophil counts,and the pathological changes of lung tissue were observed.Results Compared with CON group,BALF cell count and eosinophil count in the model group were increased obviously,which in the treatment group were significantly decreased.The effect of the X1 group and X2 group had statistical difference between on 5 d and 15 d.(P＜0.05 or P＜0.01);the treatment groups could reduce the pathogenical infiltration,lung bullae production and airway epithelial thickening of mouse lung tissue,especially the inflammation damage in X2 group was mild.Conclusion Qingqihuatan Decoction can relieve the airway inflammation and improves the lung tissue inflammatory response in model mouse.
