Level of Alpha-Synuclein Oligomers in Speripheral Blood Plasma and Red Blood Cells in Parkinson's Disease
10.3969/j.issn.1006-9771.2017.09.022
- VernacularTitle:帕金森病患者血浆和红细胞α-突触核蛋白寡聚体水平及临床意义
- Author:
Yang LIANG
;
Ying GU
;
Xiaohong LI
- Keywords:
Parkinson's disease;
alpha-synuclein oligomer;
peripheral blood;
plasma;
red blood cells
- From:
Chinese Journal of Rehabilitation Theory and Practice
2017;23(9):1096-1098
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the level of alpha-synuclein (α-syn) oligomers in peripheral blood plasma and red blood cells (RBC) in patients with Parkinson's disease (PD), and the value of it for diagnosis and evaluation of PD. Methods From March, 2013 to De-cember, 2014, peripheral blood samples were collected from 30 PD patients and 30 healthy coutrols, and the level ofα-syn oligomers in plas-ma and RBC was detected with enzyme linked immunosorbent assay. Results The level of α-syn oligomers was less in both plasma and RBC in the controls than in the patients (t>2.346, P<0.05), and was more in RBC than in plasma in both the controls and the patients (t>2.242, P<0.05). The level ofα-syn oligomers of patients did not correlate with their course, Hoehn-Yahr Stage, the scores of Unified Parkin-son Disease Rating Scale Part 3, Non-Motor Symptom Quest and Mini-Mental State Examinatlon, both in plasma and RBC (P>0.05). Con-clusion The level ofα-syn oligomers in peripheral RBC and plasma may be helpful for diagnosis of PD, but less for the evaluation of the ill-ness.
