Postoperative Stimulated Thyroglobulin Level in Predicting Functional Metastasis of Differentiated Thyroid Carcinoma
10.3969/j.issn.1005-5185.2017.06.006
- VernacularTitle:术后刺激性甲状腺球蛋白水平预测分化型甲状腺癌功能性转移灶的价值
- Author:
Peng CHEN
;
Changxiang SONG
;
Wu LU
;
Yong LIU
;
Peng DU
- Keywords:
Thyroid neoplasms;
Thyroidectomy;
Thyroglobulin;
lodine radioisotopes;
Neoplasm metastasis;
Ultrasonography,Doppler,color;
Tomography,emission-computed,single-photon;
Tomography,X-ray computed
- From:
Chinese Journal of Medical Imaging
2017;25(6):422-424,429
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To explore the value of postoperative stimulated thyroglobulin (ps-Tg) level in predicting functional metastasis in patients with differentiated thyroid carcinoma (DTC) before 131I therapy,in order to guide 131I therapy.Materials and Methods 101 DTC patients who accepted total thyroidectomy and lymphadenectomy in the First People's Hospital of Lianyungang were retrospectively analyzed.The ps-Tg level after DTC surgery was detected 1 day before 131I therapy,and 131I-SPECT/CT scan was performed 5-7 days after 131I therapy.The presence of functional metastasis was confirmed on the basis of 131I-SPECT/CT imaging,and the patients were assigned into non-metastic (M0) group and metastatic (M1) group.The ROC curve was used to evaluate the value of ps-Tg in predicting functional metastasis.Results The ps-Tg level in M 1 group was higher than that in M0 group,and the difference was statistically significant (U=328.00,P＜0.001).The area of ps-Tg value under the ROC curve was 0.870,and the diagnostic cut-off point was 40.60 ng/ml.The sensitivity,specificity and accuracy was 72.34％,100.00％ and 87.13％,respectively.Concltsion The ps-Tg value can be used as an effective indicator to predict functional metastasis,and is able to guide 131I therapy.
