The Expression of Tumor Necrosis Factor Alpha in Breast Neoplasms and Its Relationship with Imaging Manifestations
10.13241/j.cnki.pmb.2017.23.002
- VernacularTitle:肿瘤坏死因子-α在乳腺肿瘤中的表达及其与影像学特征的关系
- Author:
Shihui TANG
;
Wei FAN
;
Zheng ZHANG
;
Ping WANG
;
Qiaoling DENG
;
Peipei XU
;
June WANG
;
Mingxia YU
- Keywords:
TNF-α;
Breast cancer;
Imaging
- From:Progress in Modern Biomedicine
2017;17(23):4406-4411
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To detect the expression of tumor necrosis factor alpha in (TNF alpha) breast cacner and its relationship with imaging features.Methods:Using immunofluorescence and flow cytometry to detect the expression of TNF-α in MDA-MB-231 and MCF-7.Collect 82 patients with mammary gland disease,which was confirmed by pathological tissue,its pathological data,imaging data,and by immunohistochemistry to detect the expression of TNF-α in breast tissues,and analyze and the relationship between its expression and the pathological features and imaging characteristics.Results:TNF-α high expression in MDA-MB-231,the expression of TNF-oα in malignant breast tumor tissue significantly higher than that in benign tumor,the expression quantity associated with lymph node metastasis,TNM stages,strengthen uniform in MRI,the boundary and the shape of the X-ray Mammography (P=0.01),and color flow signal strength in ultrasound (P＜0.05).Conclusions:TNF alpha in breast tumor tissue was unusually high expression,and is closely related to some of the imaging features of breast tumor.
