Periostitis and squamous cellcarcinoma induced by long-term use of voriconazole
10.3969/j.issn.1001-1978.2017.10.005
- VernacularTitle:长期使用伏立康唑引发的骨膜炎和鳞状细胞癌
- Author:
Lihong SHI
;
Huilan LI
;
Miaomiao ZHU
;
Zanling ZHANG
- Keywords:
voriconazole;
long-term treatment;
adverse reaction;
periostitis;
squamous cell carcinoma;
mechanism
- From:
Chinese Pharmacological Bulletin
2017;33(10):1350-1353
- CountryChina
- Language:Chinese
-
Abstract:
Voriconazole is a broad spectrum triazole antifungal agent, widely used in the prevention and treatment of invasive fungal diseases.Long-term use of voriconazole can induce periostitis and cutaneous squamous cell carcinoma, accounting for serious adverse effects on patients, which has been reported in increasing clinical cases.This review is to characterize the epidemiological and clinical manifestations of periostitis and squamous cell carcinoma induced by voriconazole, and to analyze the mechanisms of triggering periostitis and squamous cell carcinoma, so as to promote the rational use of voriconazole in clinics.
