Research progress in mechanism of oxidative stress in alcoholic liver disease
10.3969/j.issn.1001-1978.2017.10.006
- VernacularTitle:氧化应激在酒精性肝病中作用机制的研究进展
- Author:
Ting XIA
;
Jin ZHANG
;
Jiahui YAO
;
Yu ZHENG
;
Jia SONG
;
Min WANG
- Keywords:
alcohol metabolism;
oxidative stress;
alcoholic liver disease;
signaling pathway;
pathogenesis;
liver injury
- From:
Chinese Pharmacological Bulletin
2017;33(10):1353-1356
- CountryChina
- Language:Chinese
-
Abstract:
Harmful substances are produced during the metabolism of alcohol in the human body, which causes liver disease.The mechanism of oxidative stress is the main pathogenesis of alcoholic liver disease, which plays a major role in the occurrence and development of alcoholic liver disease.Alcohol-induced oxidative stress mediated by reactive oxygen species(ROS)/reactive nitrogen species(RNS) brings about liver disease via apoptotic signaling pathway and MAPK signaling pathway, and alleviates liver disease through Nrf2 signaling pathway.In this paper, the studies on the mechanism of oxidative stress in alcoholic liver disease are reviewed.
