Effect of Metformin Combined with Insulin Aspart on Serum Cholesterol, Total Bilirubin, Uric Acid, Urinary Micro Protein Levels, Matemal and Infant Outcomes of Gravida with Gestational Diabetes Mellitus
10.13241/j.cnki.pmb.2017.23.025
- VernacularTitle:二甲双胍联合门冬胰岛素对妊娠期糖尿病患者血清胆固醇、总胆红素、尿酸和尿微量蛋白水平及母婴结局的影响
- Author:
Xiaoyan BAO
;
Renli LI
;
Liyun ZHANG
;
Qiufang JING
;
Hongtao LI
- Keywords:
Gestational diabetes mellitus;
Metformin;
Insulin aspart;
Matemal and infant outcomes
- From:
Progress in Modern Biomedicine
2017;17(23):4510-4513
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the effect ofmetformin combined with insulin aspart on the serum cholesterol(TC),total Bilirubin (TBil),uric Acid(UA),urinary Micro Protein(mAlb) levels and Maternal and Infant Outcomes of gravida with Gestational Diabetes Mellitus.Methods:84 patients ofgestational diabetes mellitus who received therapy from June 2014 to June 2016 in our hospital were selected.According to random number table,those patients were divided into the observation group (n=42) and the control group (n=42),on the basis of routine treatment,The control group was treated with insulin aspart,while the observation group was combined with metformin hydrochloride.The blood glucose index and the levels of TC,TBil,UA,mAlb and maternal and infant outcomes were compared.Results:After treatment,the levels of fasting blood glucose (FBG),postprandial 2h blood glucose (2hPG),glycosylated hemoglobin (HbA1c),TC,TBil,UA and mAlb in the observation group were significantly lower than the control group,the levels of TBil was significantly higher than the control group (P＜0.05);the incidence ofgestational hypertension,hydramnios,premature birth,cesarean section,giant child and neonatal jaundice were significantly lower than the control group (P ＜0.05).Conclusion:Metformin combined with insulin aspart was well for gestational diabetes mellitus,which could effectively improve the blood glucose indicators and TC,TBil,UA,mAlb levels,maternal and infant outcomes.
