Effects of Nrf2-ARE signal path on levrtiracetam anti-epileptic andlevrtiracetam on learning and memorizing ability
10.3969/j.issn.1001-1978.2017.10.026
- VernacularTitle:Nrf2-ARE信号通路在左乙拉西坦抗癫痫中的作用
- Author:
Ke WU
;
Wenli ZHAO
;
Yueying LI
;
Changyu QIU
;
Haijing SHI
;
Yongmei ZHANG
- Keywords:
epilepsia;
Nrf2;
ARE;
signal path;
levrtiracetam;
learning and memorizing ability
- From:
Chinese Pharmacological Bulletin
2017;33(10):1462-1466
- CountryChina
- Language:Chinese
-
Abstract:
Aim To explore the effects of Nrf2-ARE signal path on levrtiracetam anti-epileptic and levrtiracetam on learning and memorizing ability.Methods Thirty-six SD rats were divided into normal saline group, levrtiracetam group, model group and treatment group.Each group recruited nine rats.Tests of Morries water maze were given to the rats to evaluate their learning and memorizing ability.The protein expression of nuclear factor (erythroid-derived2)-like2 (Nrf2), heme oxygenase 1(HO-1) and NAD(P)H quinone oxidoreductase(NQO1) were examined by Western blot.Results Compared with model group, levrtiracetam could shorten the plateau period in epileptic rats (P<0.05), and increase the expression of Nrf2 protein, HO-1 protein and NQO1 protein in hippocampus(P<0.05).Conclusions Levrtiracetam could improve the learning and memorizing ability in epileptic rats.Levrtiracetam may increase the expression of HO-1 protein and NQO1 protein through the Nrf2-ARE pathway and play a part in antiepileptic effects.
