The relationship between inflammatory factor expression and cell apoptosis in gingival tissue of the subjects with diabetes associated periodontitis
10.3969/j.issn.1001-3733.2017.04.019
- VernacularTitle:糖尿病型牙周炎牙龈组织中炎症因子表达及与细胞凋亡关系
- Author:
Tielou CHEN
;
Xinhai ZHANG
;
Erli XU
;
Dahai TANG
;
Haijun ZHAO
;
Yimin XU
;
Xiaoli ZHANG
;
Wei LUAN
;
Jin LIU
;
Jun CHEN
;
Liting MA
- Keywords:
Cell apoptosis;
Diabetes associated periodontitis (DAP);
Inflammatory cytokine;
Mechanism
- From:
Journal of Practical Stomatology
2017;33(4):518-521
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the relationship between IL-1β and TNFα expression and cell apoptosis in gingival tissue of the subjects with diabetes associated periodontitis(DAP).Methods:20 cases of DAP(group DAP) and 20 cases of health controls(group H)were included.The cell apoptosis and the ultrastructural changes in gingival tissue were observed by Tunnel staining and transmission electron microscope (TEM).IL-1β and TNFα expression in gingival tissue were detected by immunohistochemical staining.SBI,GI,PD and AL of the subjects were measured.The relationship between the level of IL-1β,TNFα and the cell appotosis was analyzed.Results:Apoptosis was obvious in prickle cells and basal cells of gingival tissue of DAP group.The percentage of apoptosis cells of DAP group was significantly higher than that of group H(P＜0.01).The expression of IL-1β and TNFα in group DAP was significant higher than that of group H (P＜0.01),and the mainly positive expression cells were macrophages,plasmocytes and lymphocytes.Conclusion:IL-1β and TNFα play a role in cell apoptosis in the gingival tissue of the patients with DAP.
