The effects and safety of triamcinolone acetonide oral ointment in the treatment of erosive oral lichen planus
10.3969/j.issn.1001-3733.2017.04.023
- VernacularTitle:曲安奈德口腔软膏治疗充血糜烂型口腔扁平苔藓的疗效及安全性观察
- Author:
Qinglan LIU
;
Lin LIU
;
Liuyang LI
;
Yuan FAN
- Keywords:
Triamcinolone acetonide oral ointment (TAOO);
Erosive oral lichen planus (EOLP);
Fungal infection
- From:
Journal of Practical Stomatology
2017;33(4):536-540
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the effects and safety of triamcinolone acetonide oral ointment in the treatment of erosive oral lichen planus(EOLP).Methods:62 cases with EOLP were randomly divided into 2 groups.The patients in test group(n =29) were treated by local application of triamcinolone acetonide oral ointment (TAOO),oral administration of hydmxychloroquine(HCQ) and gargle with cetylpyridinium chloride buccal tablets(CCBT),in control group (n =33) by HCQ and CCBT.The patients were followed up for 4 weeks.The changes of the erosion area and the VAS pain degree of the patients were analysed at the first visit,the second week and the fourth week follow-up respectively.The safety indexes were examined at the first visit and the fourth week follow-up respectively.Results:TAOO accelerated the erosion surface healing of EOLP in 2 weeks(P ＜ 0.05),and reduced the pain index of the patients (P＜0.05),but after 4 week treatment,no significant difference was observed between 2 groups (P ＞ 0.05).Fungal infection was found in 4 cases in test group.Conclusion:Local application of TAOO combined with oral administration of HCQ and gargle with CCBT is more effective than HCQ and CCBT in the treatment of EOLP,attention should be paid to prevent fungal infection.
