The research progress of microRNA on regulation of drug disposition in vivo
10.3969/j.issn.1001-1978.2017.10.004
- VernacularTitle:microRNA对药物体内过程调控的研究进展
- Author:
Hui LI
;
Jianzhong RUI
- Keywords:
microRNA;
epigenetics;
drug-metabolizing enzyme;
drug transporter;
interindividual variability;
rational use of drug
- From:
Chinese Pharmacological Bulletin
2017;33(10):1345-1349
- CountryChina
- Language:Chinese
-
Abstract:
The disposition of drug in vivo is subjected to a series of biotransformation and transport, depending on the involvement of drug-metabolizing enzymes and transporters.However, the individual capacity varies when metabolizing and transporting the same drug, and pharmacogenomics has trouble in completely explaining the differences.microRNA, a key aspect of epigenetic modifications, is a powerful complement to traditional genetics.Emerging evidences have confirmed that drug-metabolizing enzymes and transporters be controlled by different microRNAs, and the same microRNA also regulates several drug-metabolizing enzymes or/and transporters simultaneously.All of these researches infer that microRNAs are likely to realize the comprehensive macro-regulation of gene expression.The further study of microRNAs maybe a suitable point to research the interindividual variability in disposition of drugs, and it provides a theoretical basis for rational use of drug and individualized medicine.
