Effects of Omeprazole Combined with Somatostatin on Intra-Abdominal Pressure and Intestinal Mucosal Barrier Function of Elderly Patients with Severe Acute Pancreatitis
10.13241/j.cnki.pmb.2017.24.017
- VernacularTitle:奥美拉唑联合生长抑素对老年重症胰腺炎腹内压及肠道粘膜屏障功能的影响
- Author:
Hui ZHANG
;
Niu SHI
;
Miao ZHANG
;
Yuting YUN
;
Jie SONG
- Keywords:
Omeprazole;
Somatostatin;
Elderly;
Severe acute pancreatitis;
Intra-abdominal hypertension;
Intestinal mucosal barrier function
- From:
Progress in Modern Biomedicine
2017;17(24):4672-4675
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effects of omeprazole combined with somatostatin on intra-abdominal pressure and intestinal mucosal barrier function of elderly patients with severe acute pancreatitis.Methods:Selected 82 cases of elderly patients with severe acute pancreatitis from our hospital.They were divided into research group (48 cases) and control group (34 cases).The control group was treated with basic therapy,and the research group was treated with omeprazole combined with somatostatin on the basis of the control group.Analyzed and compared the clinical effects,intestinal mucosal barrier function and symptom indexes of patients in the two groups.Results:①The total effective rate of the research group was significantly better than that of the control group,and the difference was statistically significant (P=0.005).②After treatment,the D-lactose and diamine oxidase (DAO) levels of both groups were significantly lower than before treatment,and the difference was statistically significant (both P＜0.001).In addition,after treatment,the D-lactose and DAO levels were significantly lower in the research group than in the control group,and the differences were statistically significant (mean P ＜ 0.001).③After treatment,patients of the research group showed better results in abdominal pain and abdominal distension relief time,bowel recovery time,hospital stay and blood amylase index than those in the control group,and the difference was statistically significant (mean P ＜ 0.001).④After treatment,the intra-abdominal hypertension of two groups was significantly lower than before treatment,with statistical difference (P ＜ 0.001).Yet it was significantly lower in the research group than in the control group,with statistical difference (P ＜ 0.001).Conclusion:The combined treatment of omeprazole and somatostatin can effectively improve the clinical efficacy of severe acute pancreatitis in elderly patients,correct intra-abdominal hypertension and improve the intestinal mucosal barrier function of patients,so it is worthy of reference and promotion.
