Research Progress on the Function and Structure of Solute Carrier Superfamily Transporters
10.13241/j.cnki.pmb.2017.24.043
- VernacularTitle:溶质转运蛋白超家族的功能及结构研究进展
- Author:
Yue WANG
;
Binghong XU
;
Hu LIU
;
Chaoguang JI
;
Hanchi YAN
- Keywords:
Solute carriers;
Function;
Disease;
Structure
- From:Progress in Modern Biomedicine
2017;17(24):4775-4783,4793
- CountryChina
- Language:Chinese
-
Abstract:
Solute Carriers (SLC) superfamily is one of the most important membrane transporter families in the cell membrane (including intracellular membrane) of human,it is involved in some essential physiological functions such as intercellular substance transporting,energy transfer,nutrition and metabolism,signal transduction and so on.Solute Carriers (SLC) superfamily contains 52 subfamilies,with more than 400 members.Studies have shown that abnormal protein expression or functional defects of SLC caused by human genetic mutations are closely related with a variety of serious diseases such as diabetes,hypertension and depression,so the function research of SLC had attracted much attention in recent years.The known three-dimensional structures of SLC transporters help to explain the precise molecular mechanism of substrate binding and transporting,it provides a fine structure basis to study the molecular mechanism of related diseases and structure-based drug discovery.In this review,we summarized the progress on the structure and function of SLC superfamily transporters of late years,try to provide some common rules of SLC superfamily transporters.
