The impact of initial periodontal therapy on the peripheral blood MMP-3 and IFN-γ levels in patients with oral lichen planus and chronic periodontitis
10.3969/j.issn.1001-3733.2017.04.025
- VernacularTitle:牙周基础治疗对口腔扁平苔藓伴慢性牙周炎患者外周血MMP-3及IFN-γ水平的影响
- Author:
Huimin GONG
;
Hongchi ZHANG
;
Ruimin ZHANG
- Keywords:
Oral lichen planus(OLP);
Chronic periodontitis(CP);
IFN-gamma;
MMP-3;
Periodontal initial therapy
- From:
Journal of Practical Stomatology
2017;33(4):546-549
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the significance of periodontal treatment on the levels of MMP-3 and IFN-γin the serum of patients with oral lichen planus(OLP) and chronic periodontitis(CP) before and after treatment.Methods:60 patients with erosion OLP and CP were divided into 2 groups randomly (n =30).The patients in experimental group received basic periodontal treatment combined with drug therapy,those in control group received drug therapy only.Before and after treatment the periodontal indexes of PD,AL,BI and PLI were measured in the experimental group,the levels of MMP-3 and IFN-γ in serum were tested by ELISA in the 2 groups,the differences of the data between 2 groups were statistically analysed.Results:After treatment the periodontol indexes were decreased in the experimental group(P ＜ 0.05),the serum MMP-3 and IFN-γ levels were lower than those before treatment in 2 groups(P＜0.05),and the decline of MMP-3 and IFN-γ in experimental group was more obvious than those in the control group (P＜0.05).Conclusion:Periodontal initial therapy has positive influence on the treatment of OLP and can reduce the level of inflammation.
